Application and preparation of potassium glycyrrhizate_Kain Industrial Additives

Overview^[1-2]

Licorice has a long history of being used as medicine. The “Shen Nong’s Materia Medica” lists it as the best medicine, and ancient medical scientists respectfully call it “the old man of the country”. Due to its precious resources, it is listed as a national second-level protected wild medicinal material. Potassium glycyrrhizinate is widely used in medicine, food, cosmetics and other industries, and the market demand is large.

Apply^[3-4]

Potassium glycyrrhizinate is widely used in medicine, food, cosmetics and other industries, and the market demand is large.

1) Prepare a multifunctional cigarette paper, which is characterized by adding an improving agent during the production process of the cigarette paper. The improving agent is potassium glycyrrhizinate, and the potassium glycyrrhizic acid salt is monopotassium glycyrrhizinate, glycyrrhizic acid Any one, two or three combinations of dipotassium or tripotassium glycyrrhizate; the dosage ratio of the cigarette paper and potassium glycyrrhizinate is the following parts by weight: cigarette paper 99.8~99.95, potassium glycyrrhizinate 0.05 ~0.2. These three products are used as improvers for cigarette paper. The single component or mixed components of the improvers are added to the cigarette paper. They not only have the effect of supporting the combustion of the cigarette paper, but also can adjust the wood gas caused by the burning of the cigarette paper when smoking cigarettes. It brings little discomfort to the senses and little change to the original flavor of tobacco. It improves the aroma texture and roundness of cigarette smoke, improves mouthfeel comfort and taste. The cigarette paper also has a sweet taste, which increases consumers’ desire to smoke. pleasure.

2) Prepare a silk fibroin anti-inflammatory moisturizing cream. The raw materials are: deionized water, silk peptide, ellagic acid, jojoba oil, horse chestnut, sorbitan monooleate, carnosine, 1,2 -Pentylene glycol, glycerin, potassium glycyrrhizinate, chamomile, alkyl polyglucoside, vitamin C, collagen and essence; effectively prevent skin roughness, keep skin moisturized and smooth and prevent skin darkening; quickly penetrate into the skin The inner layer can effectively remove the aging keratinocytes of the skin, promote cell metabolism, maintain skin elasticity, and make the skin smooth and delicate; promote the absorption of nutrients, promote skin metabolism, have a moisturizing effect and moisturize the skin, while whitening the skin, it also greatly reduces the skin’s free radicals in the skin, effectively delaying aging. For acne patients, apply 1-4 times a day, 0.5-1.5ml each time. Acne will subside in 3-5 days, and acne marks will be removed in 6-10 days. It is anti-inflammatory and anti-allergic, and effectively protects the elasticity of the skin.

Preparation^[1-2]

Method 1: The method for preparing potassium glycyrrhizinate includes the following steps:

(1) Take ammonium glycyrrhizinate salt, add an appropriate amount of water and dissolve it at a certain temperature to obtain ammonium glycyrrhizinate salt solution.

(2) Take the ammonium glycyrrhizinate solution and pass it through a certain type of resin column. After the column is completed, add water to fully elute and remove other impurities, then use a solution containing a certain concentration of potassium ions to elute, and collect the eluate , concentrated under reduced pressure to a certain volume to obtain glycyrrhizic acid potassium salt concentrate.

(3) Take the concentrated solution, add an appropriate amount of organic solvent, stir, leave to crystallize, filter, and dry to obtain potassium glycyrrhizinate.

Method 2: A method of extracting glycyrrhizic acid potassium salt from licorice.

1. Leaching: Crush the licorice into 30-100 mesh, put it into 2-10 containers, add water, stir, soak in water for 20-120 minutes, filter, and obtain the licorice leaching aqueous solution;

2. Vacuum evaporation: The negative pressure in the container is 8000-10000 Pascal, so that the licorice leached aqueous solution becomes a paste;

3. Acid precipitation: Drop 1% – 10% hydrochloric acid or sulfuric acid into the paste licorice leaching aqueous solution at a dripping speed of 1 kg/h – 15 kg/h, stir in one direction, so that the ph value is 1-5;

4. Add catalase: In the above paste licorice leaching solution, add 1-3% acetone with a concentration of more than 95%, and dropwise add 15-20% potassium hydroxide ethanol solution, and filter to dry Finally, tripotassium glycyrrhizinate is obtained;

5. Dissolve tripotassium glycyrrhizinate in more than 95% glacial acetic acid, and detect that the pH value is neutral. Leave to cool, and the crystallization will become monopotassium glycyrrhizinate.

Main reference materials

[1] CN201010264190.X Preparation method of potassium glycyrrhizinate

[2] CN97119945.0 A method of extracting potassium glycyrrhizinate from licorice

[3] CN200810177083.6 Multifunctional cigarette paper and preparation method thereof

[4] CN201810518728.1 Preparation method of silk fibroin anti-inflammatory moisturizing cream