VERTELLUS Hydrophilic super slippery coating for medical devices Biocompatible cross-linkable phosphorylcholine coating PC1036

PC Technical Introduction
PC is the abbreviation of phosphorylcholine, which exists in various phospholipids, especially in The chemical name for the polar headgroups in phospholipids that make up the bilayer structure of cell membranes.
PC technology is a proprietary technology platform of methacrylic acid polymers containing phosphorylcholine. These biomimetic materials are built on the body's own chemistry, yet they are entirely synthetic, allowing precise control over purity, molecular structure, and avoiding the risks associated with animal-derived ingredients. They can provide a simple and effective solution to the biosensitivity challenges faced by medical devices and can be tailored to specific application needs.

Products Checklist
Ventruus Biomaterials offers a wide range of polymer coatings and monoliths to utilize PC Various features and benefits that can be provided:

polymer

Summary

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PC1036

Standard cross-linked PC coating, high durability drug delivery matrix

BiodivYsio® Dexamet® TriMaxx™, Endeavor® Stent

PC1059

Standard non-crosslinked PC coatings are stabilized by hydrophobic surface interactions

Guide wire, CPB system

PC2118

Cross-linked PC coating, high content of PC forms a self-wetting surface

Blood Filtration and Treatment

PC1062

Cross-linked PC coating, with low content of positive charge, can bind heparin to form antithrombotic Blood Coating

Blood Filtration and Treatment

PC2028

Cross-linked PC coating, high content of positive charge, can be used for high molecular weight drug delivery Matrix

BiodivYsio Matrix Hi bracket

PC1071

In-mold PC coating with vinyl functional groups for curable materials , such as ketone silicone

<span st Filter without PC technology

b. Reduce blood activation

Blood filter with PC technology Blood filter without PC technology

c. Reduce biofilm formation

Ureter with PC technology Ureter without PC technology

PC Applications of Technology™ in non-medical fields
It is clear that the non-fouling and surfactant properties of PC have potential in non-medical applications benefits.
Some examples of applicable properties, benefits, and potential applications are summarized below:

Performance	Advantages	Potential application areas
Reduce protein attachment	Reduced fouling; easier to clean	Food and beverage processing equipment; pharmaceutical processing equipment
Reduce protein attachment	Reduce use of harsh cleaning chemicals	Non-toxic marine antifouling
Reduces bacterial adhesion and biofilm formation	Ditto, while reducing the risk of infection/contamination/spoilage	Used in hospitals to maintain clean/easy-to-clean surfaces; water filtration systems; latex
hydrophilicity and moisture retention	Intensive moisturizing and conditioning	Cosmetics; Functional/Active Textiles
Deliver active substances	Active substances and benefits mentioned above	cosmetics; health products

PC Technology™ in Drug Delivery
In recent years, the development of drug-device combination products has Significant changes. Perhaps the clearest example has always been the drug-eluting stent (DES) market, which has exploded from $1.5 billion to $5 billion in two years. PC coating has played an important role in this field. Abbott's PC dimethasone stent, Dexamet®, the second DES to market in Europe, and Medtronic's PC-coated otarolimus-eluting Endeavor® DES system, were notable in a two-year follow-up of 1,300 patients In the trial, there was no late frame thrombosis. These application examples highlight the value of PC materials to the medical device market.
The flexible chemical properties of PC polymers make it possible to modify various monomers, so that the polymers can be customized according to different active substances and the drug elution performance can be fine-tuned. Breakthrough drug-device combinations that demonstrate clinical benefits through controlled drug release, and Ventruus' expertise is well suited to serve the development and commercialization of combination products.

PC coating can:
o Adsorption of high molecular weight compounds
o Absorption of low molecular weight drugs
o Exhibit precise dosing and controlled release
o Once released, remain stable

PC coating can deliver:
o Anti-inflammatory drugs o Pain relievers
o Antimicrobials o Hormones
o DNA fragments used in gene therapy

Specific examples of active substances that have been studied:
o Dexamethasone o Estradiol
o Paclitaxel o Sirolimus
o Batimastat o Angiopep
o Dipyridamole

Manufacturer Information
The headquarters and application laboratory of Ventrus Biomaterials are located in Hampshire, UK. The division is part of Van Truust Specialty Products UK Limited in the North of England and the company's operations are accredited to an ISO9001:2008 Quality Management System (Certificate No. FM02222). Van Truus Specialty Products UK Ltd has facilities to produce multi-tonne PC materials and has recently opened a new polymer chemistry R&D laboratory to support the Biomaterials Division's operations. Ventrux is ideally suited to assist medical supply companies in applying the benefits of PC technology to address unmet clinical needs and provide value-added, differentiated products.

The value of PC materials to the medical device market.
The flexible chemical properties of PC polymers make it possible to modify various monomers, so that the polymers can be customized according to different active substances and the drug elution performance can be fine-tuned. Breakthrough drug-device combinations that demonstrate clinical benefits through controlled drug release, and Ventruus' expertise is well suited to serve the development and commercialization of combination products.

PC coating can:
o Adsorption of high molecular weight compounds
o Absorption of low molecular weight drugs
o Exhibit precise dosing and controlled release
o Once released, remain stable

PC coating can deliver:
o Anti-inflammatory drugs o Pain relievers
o Antimicrobials o Hormones
o DNA fragments used in gene therapy

Specific examples of active substances that have been studied:
o Dexamethasone o Estradiol
o Paclitaxel o Sirolimus
o Batimastat o Angiopep
o Dipyridamole

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