The laurel azone industry has a sound foundation for development and China’s production capacity continues to increase

Laurezone, whose chemical name is 1-n-dodecylazepan-2-one, is an organic compound with the chemical formula C18H35NO. It appears as a colorless to slightly yellow clear oily liquid, odorless and almost tasteless. According to different solubility, laurel azone can be divided into two categories: water-soluble laurel azone that is soluble in water and oil-soluble laurel azone that is only soluble in organic solvents.

Laurezone is a type of highly efficient and safe penetrating agent developed in the early 1980s. It has an obvious penetration-assisting effect on both hydrophilic and lipophilic compounds. After development in recent years, research on laurel azone has continued to deepen, and the production process has continued to increase. The main processes include sodium hydride method, sodium alcohol method, water separation synthesis method, solid-liquid phase transfer catalytic method, ultrasonic phase transfer catalytic method, and non-toxic phase transfer catalytic method. Water KF synergistic catalysis method and many other methods.

Among them, the solid-liquid phase transfer catalytic method is currently a common method for producing laurel azone at home and abroad. It refers to a method that uses caprolactam and bromine as raw materials and reacts in toluene or ethane solvent to produce laurel azone. It has the advantages of simple process and operation It has the advantages of short process, low production cost and high product yield. The increasingly mature production technology has laid a good foundation for the development of the laurel azone industry.

According to the“Research Report on Market Monitoring and Future Development Prospects of China’s Laurel Azone Industry from 2023 to 2027” released by the Industrial Research Center It shows that laurel azone is a new, efficient and safe transdermal absorption accelerator, which can be widely used in medicine, pesticides, daily chemicals, chemical fibers, printing and dyeing, oil exploration and other fields. In the field of medicine, laurel azone is mainly used as an auxiliary drug for external use such as creams, ointments, and liniments; in the field of pesticides, laurel azone is mainly used as an adsorbent for plant growth regulators and a facilitator for bactericidal insecticides. Penetrating agent; in the field of daily chemicals, laurel azone is mainly used as various cream cosmetics and hair products; in the fields of leather, printing and dyeing, laurel azone is mainly used as a coloring accelerator.

Compared with other accelerators and penetrants such as dimethyl sulfoxide and alcohol compounds, laurel azone has the advantages of good lubricity, strong permeability, non-toxicity, high safety and good chemical stability. Currently, as the advantages of laurel azone continue to be highlighted, its application fields continue to expand, market demand continues to increase, and the industry shows good development prospects.

Industry analysts said that currently there are not many laurel azone manufacturers in my country, the main ones are Huludao Laurel Azone Chemical, Suzhou Shenglong New Material Technology, Henan Senhui Agricultural Technology, Jiangsu Nanfang Weisai Pharmaceutical, Chongqing Huabang Shengkai Pharmaceutical, Jinan Jinda Pharmaceutical, Xinxiang Gaojin Pharmaceutical, Hubei Kejie Pharmaceutical, etc. As local companies continue to upgrade their technology, my country’s laurel azone production capacity continues to increase, and its production capacity will exceed 5,000 tons in 2022.