Furosemide Furosemide

Frusemide structural formula

Structural formula

Business number 016C
Molecular formula C12H11ClN2O5S
Molecular weight 330.74
label

furosemide,

Diuretic,

furaniline,

sulfonamide,

Abdominal acid,

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid,

5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

Numbering system

CAS number:54-31-9

MDL number:MFCD00010549

EINECS number:200-203-6

RTECS number:CB2625000

BRN number:None

PubChem number:24277714

Physical property data

1. Character:White or off-white crystalline powder, odorless, almost tasteless.


2. Density (g/mL,25/4): Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point (ºC): 206


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC,5.2kPa): Undetermined


7. Refractive index: undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC): Undetermined


Molar volume (m3/mol ): 205.8


3. isotonic specific volume (90.2K):606.2


4. Surface Tension (dyne/cm):75.2


5. Polarizability10-24cm3):30.03


Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 7

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 4

6. Topological molecule polar surface area 131

7. Number of heavy atoms: 21

8. Surface charge: 0

9. Complexity: 481

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a cool, dry place.

Synthesis method

By 2, 4-Dichlorobenzoic acid (see 12740) undergoes chlorosulfonation, amination, and acidification to obtain 2, 4-Dichloro-5-Sulfamoylbenzoic acid. It is then condensed with furfurylamine to produce furosemide.

Purpose

This product has a strong but short-lived diuretic effect. It is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.

AMILY: 宋体”>From 2, 4- dichlorobenzoic acid (see 12740) through chlorosulfonation, ammoniation and acidification to obtain 2, 4-dichloro-5-Sulfamoyl benzoic acid. It is then condensed with furfurylamine to produce furosemide.

Purpose

This product has a strong but short-lived diuretic effect. It is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.

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