Methotrexate Methotrexate

Structural formula

• Numbering system
• Physical property data
• Toxicological data
• Ecological data
• Molecular structure data
• Computing chemical data
• More
  • Properties and Stability
  • Storage method
  • Synthesis method
  • Purpose

Numbering system

CAS number:59-05-2

MDL number:MFCD00064370

EINECS number:200-413-8

RTECS number:MA1225000

BRN number:70669

PubChem number:24897373

Physical property data

1. Characteristics: yellow crystal. Odorless.

2. Density (g/mL,25/4℃): Undetermined

3. Relative vapor density (g/mL,air=1): Undetermined

4. Melting point (ºC): Undetermined

5. Boiling point (ºC,Normal pressure): Undetermined

6. Boiling point (ºC,5.2kPa): Undetermined

7. Refractive index: Undetermined

8. Flashpoint (ºC): Undetermined

9. Specific optical rotation (º): SPAN>Undetermined

10. Autoignition point or ignition temperature (ºC): Undetermined

11. Vapor pressure (kPa,25ºC9. Complexity: 704

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 1

12. The number of uncertain atomic stereocenters: 0

13. Determine the number of stereocenters of chemical bonds: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

Sealing4Store dry at ℃.

Synthesis method

By2,4,5,6- It is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.

Purpose

Folic acid antagonizes Liu. A potent inhibitor of dihydrofolate reductase. Immunosuppressants. Tissue culture reagents.

This product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. Oral methotrexate12hAfter the original drug90%Excreted in urine, the main metabolite is7-Hydroxymethotrexate. Intravenous injection in ratsLD50 for14mg/kg.

font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt”>,4,5,6-It is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.

Purpose

Folic acid antagonizes Liu. A potent inhibitor of dihydrofolate reductase. Immunosuppressants. Tissue culture reagents.

This product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. Oral methotrexate12hAfter the original drug90%Excreted in urine, the main metabolite is7-Hydroxymethotrexate. Intravenous injection in ratsLD50 for14mg/kg.