Magnesium stearate is a loose white powder with a smooth feel. It is insoluble in water, ethanol and ether, but soluble in hot water and ether. It decomposes into stearic acid when exposed to acid. and the corresponding magnesium salts. The solubility in room temperature water is 77-79 mg/L, and it is soluble in hot ethanol. It has a slight odor and a greasy feel.
Magnesium stearate can be used as pharmaceutical excipients:
Magnesium stearate pharmaceutical tablet raw material (excipients, lubricants), is a new Pharmaceutical excipients can be used as film-forming coating materials for solid preparations, thickeners and suspensions for colloidal liquid preparations, etc. Drugs incompatible with magnesium stearate include: aspirin, iron salts, some vitamin drugs, alkaloid salts and drugs that are sensitive to magnesium ions – strong organic acid salts.
It should be noted that some drugs are incompatible with magnesium stearate:
1. Drugs containing carboxyl groups: nifedipine, cefixime Lo, ibuprofen, clarithromycin, ramipril, levofloxacin, diclofenac, ketorolac, trandolapril.
2. Organic salts: fosinopril sodium, clopidogrel acetate.
3. Drugs containing sulfhydryl groups: omeprazole, azathioprine.
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