[Sorbitol Supply] The role of sorbitol in compound amino acid injection

Sorbitol, also known as sorbitol. It is white hygroscopic powder or crystalline powder, flakes or granules, odorless. Depending on the crystallization conditions, the melting point changes in the range of 88~102℃, and the relative density is about 1.49. Easily soluble in water (1g dissolves in about 0.45mL water), slightly soluble in ethanol and acetic acid. It has a refreshing sweetness, the sweetness is about half that of sucrose, and its caloric value is similar to that of sucrose. According to the understanding of sorbitol supply: in the food industry, sorbitol liquid with a content of 69~71% is mostly used. Sorbitol liquid is a clear, colorless, syrupy liquid with a sweet taste, neutral to litmus, and miscible with water, glycerin and propylene glycol. Can be used as nutritive sweetener, humectant, chelating agent and stabilizer.

Sorbitol has diuretic and dehydrating properties, can reduce intracranial pressure and prevent edema. It can be used directly as a drug for cerebral edema and glaucoma; it can also be used for edema and oliguria with normal heart and kidney function. ; Oral administration can be used as a laxative or sucrose substitute for diabetic patients. Clinical preparations include sorbitol injection, sorbitol special injection, compound amino acid injection, etc.

Compound amino acid injection:

Sorbitol can be used to prepare compound amino acid injection, the dosage is 5%. Compound amino acid injection can be used for malnutrition, hypoalbuminemia and decreased immunity due to digestive dysfunction or inability to ingest food through the digestive tract; severe infection patients with large-area burns and traumas have strong metabolic decomposition and large protein loss, The body’s demand for nitrogen increases; in addition, use before and after surgery can improve the patient’s nutritional status, thereby reducing intraoperative and postoperative complications and mortality.

The main functions of sorbitol in compound amino acid injection are as follows:

1. It can improve the utilization of amino acids;

2. Balance the ratio of carbon to nitrogen in the injection;

3. It can avoid the Maillard reaction between the aldehyde group in the sugar and the amino group in the amino acid caused by glucose sterilization to produce pyrochrome, and it is not easy to produce heat source.

4. Keep the wound and wound surface as dry as possible to speed up healing and avoid infection.