Current safety of 1,2-hexanediol · Used for more than ten years · Skin irritation: Almost None · Eye irritation: Severe · Skin sensitization (hypersensitivity): Little from these results it can be concluded that the ingredients are generally safe in terms of cosmetic content and normal use. The following is the basis for this conclusion.
1. About skin irritation
Review security test data based on security components ( Reference 1: 2012) · [Human trial] 205 participants (42 (163 women) applied carbomer gel containing 15% 1,2-hexanediol for 48 hours during the induction and challenge phases. Responses were scored after 72 hours, with 1 in 205 showing an irritant response, but no subsequent response was observed in the 4-day repeated release patch test. · [Human trial] Carbopol gel containing 0.5% 1,2-hexanediol was used on 224 subjects (48 males, A skin irritation test was conducted on 176 women, aged 19-70 years. No skin irritation · [Human trial] When 56% of participants used a 10% aqueous solution of 1,2-hexanediol, none of the participants Causes skin irritation. · [Human trial] A gel formulation containing 0.5% 1,2-hexanediol was applied to 101 people on a 24-hour semi-occlusive patch On the participant's back, it will not cause skin irritation. · [Human trial] Twice a week, the backs of 28 participants were washed with a shower gel containing 0.15% 1,2-hexanediol. , which lasted 30 days, in which none of the participants experienced redness, puffiness, or dryness. Conclusion This product has no potential skin irritation effects. According to test data, NormallyReportAlmost no skin irritation, BecauseUsuallyReport No skin irritation.
2. Regarding eye irritation
Review security test data according to security components (Reference 1 : 2012) · A 1% aqueous solution of a mixture of 50% 1,2-hexanediol and 50% octanediol is classified as severe eye irritation Sex
Based on test data, severe eye irritation has been reported span>so there isthe potential for serious eye irritation.
3. About skin allergies
Reviewing security test data according to security components (Reference 1: 2012) · [Human trial] When 56% of the participants used a 10% 1,2-hexanediol aqueous solution, none of the participants caused skin irritation. · [Human trial] Twice a week, 28 participants Wash your back with a shower gel containing 0.15% 1,2-hexanediol for 30 days. Conclusion: This product has no potential to induce skin sensitization · [Animal Test] In the mouse skin sensitization test according to OECD429 guidelines, 10, 50, 100% of 1, 2-Hexanediol solution, skin sensitization is negative.
According to test data,UsuallyReportAlmost no skin sensitization. *** 1,2-Hexanediol is divided into basic ingredients, moisturizing ingredients and Preservative ingredients. *** Reference list: 1. "Cosmetic Ingredients Review" (2012) "Safety Assessment of 1,2-Ethylene Glycol Used in Cosmetics", "International Journal of Toxicology" (31) (5), 147S-168S. 2. "Mandom Co., Ltd." (2005), "Realization of preservative-free (additive-free) cosmetics using the antibacterial properties of alkanediol, a moisturizing ingredient", Published on January 15, 2018. 3. Yuki Moshiguchi et al. (2006) "Antimicrobial properties of pentylene glycol" Fragrance Journal (34) (4), 68-73. 4. Gerhard Schmaus et al. (2006) “Reducing preservative content in cosmetic formulations”, Fragrance Journal (34) (4), 47-52. 5. Yasumasa Taniguchi et al. (2012), "Prediction of antiseptic efficacy of cosmetics based on the prediction formula of minimum inhibitory concentration (MIC)", "Journal of Japanese Cosmetic Engineers" (46) (4), 295-300.
Author: YiyaYiko
Link ：https://www.jianshu.com/p/0c81671265e9
Source: Jianshu
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