As a kind of pharmaceutical intermediate, p-hydroxyphenylpropionic acid industry has broad development prospects.

Para-hydroxyphenylpropionic acid, also known as phloretinic acid, is a chemical substance with the molecular formula C9H10O3. It appears as a white to light yellow crystal, is irritating, is slightly soluble in water, and is soluble in ethanol, ethyl acetate and heat. Water, insoluble in benzene, chloroform, ether and other solvents.

There are various production methods for p-hydroxyphenylpropionic acid, including phenol method, hydroxybenzaldehyde method, methoxybenzaldehyde method, etc. The phenol method uses phenol as the raw material and reacts with acrylonitrile and hydrolysis under the action of aluminum trichloride to generate p-hydroxyphenylpropionic acid; the hydroxybenzaldehyde method uses hydroxybenzaldehyde as the raw material and condenses with acetic acid. , catalytic hydrogenation and other steps to generate p-hydroxyphenylpropionic acid; the methoxybenzaldehyde method uses methoxybenzaldehyde as raw material, under the action of pyridine, through reaction with malonic acid, reduction, reaction with HBr and other steps Method for producing p-hydroxyphenylpropionic acid.

Para-hydroxyphenylpropionic acid is an important type of pharmaceutical intermediate, mainly used in the production of esmolol hydrochloride, cetrixate hydrochloride and other drugs, especially the production of esmolol hydrochloride. Esmolol hydrochloride is a selective β1-adrenergic receptor blocker with rapid onset and short duration of action. It can be widely used in the treatment of tachycardia, hypertension, sinus tachycardia, etc. caused by surgery. .

According to the “Research Report on Market Monitoring and Future Development Prospects of China’s Paraben Industry from 2023 to 2027” released by the Industrial Research CenterIt shows that under the background of the accelerating aging process in China, the number of surgeries continues to rise, which in turn drives the market demand for esmolol hydrochloride to continue to increase. In 2022, the market size of esmolol hydrochloride injection in domestic hospitals has reached 960 million yuan. , a year-on-year increase of 12.4%. As a key intermediate for esmolol hydrochloride, the market demand for p-hydroxyphenylpropionic acid continues to grow, and the industry shows good development prospects.

my country’s paraben industry started relatively late, with relevant research appearing in the 1990s. However, in recent years, with the increasing use of esmolol hydrochloride, the paraben industry has developed rapidly. At present, the number of domestic hydroxyphenylpropionic acid production companies continues to increase. The main companies include Jiaye Biotechnology, Pustar Biotechnology, Rongcan Biotechnology, Zonnuo Chemical, Lianshuo Biotechnology, Xinxin Chemical, Aofite Chemical, etc. There are many companies.

Industry analysts said that p-hydroxyphenylpropionic acid is a key intermediate for esmolol hydrochloride. Currently, esmolol hydrochloride is the most popular in China. Driven by the rapid development of the Lorre market, its demand continues to increase, and the industry shows good development prospects. At present, there are a large number of paraben production companies in my country, but most of them are small and medium-sized enterprises. There is no obvious leading company yet. There is still huge room for growth for local companies in the future.