The nanoemulsion market has broad development prospects, but current practical applications still have limitations.

Nanoemulsion, also known as ultrafine emulsion, is a stable, transparent, low-viscosity dispersion system formed by water, oil, surfactants and co-surfactants in appropriate proportions. The droplet size of nanoemulsions is usually between 20-200 nanometers. Compared with ordinary dosage forms, nanoemulsions have the advantages of good stability, strong oxidation resistance, high absorption rate, good carrier performance, and high compatibilization ability.

Nanoemulsions can be divided into three types: oil-in-water nanoemulsion (O/W), water-in-oil nanoemulsion (W/O) and bicontinuous nanoemulsion. Nanoemulsions can be prepared in liquid, aerosol, foam, cream, spray, gel and other dosage forms. As a carrier tool with great potential, nanoemulsions have attracted much attention from researchers at home and abroad. As research continues to deepen, nanoemulsions are used in daily applications. Chemical engineering, environmental science, biomedicine, pesticides, food, petroleum and other fields have shown broad application prospects.

According to the “2023-2027 China Nanoemulsion Industry Market Monitoring and Future Development Prospects Research Report released by the Industrial Research Center, The application prospects of nanoemulsions are promising, but due to high production costs, expensive equipment, and difficulty in research and development, nanoemulsions still have limitations in practical applications. For example, in the field of pesticides, as of now, no nanoemulsion pesticide formulation has been registered in China.

In the field of medicine, nanoemulsion is a new type of nano drug delivery system. The administration routes include oral administration, transdermal administration, mucosal administration, intravenous injection, etc. In January 2023, the clevidipine butyrate injection emulsion of CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd., a subsidiary of CSPC, was approved by the State Food and Drug Administration to conduct clinical trials in China. Clevidipine butyrate It is the first nanoemulsion developed by CSPC Pharmaceutical Group. The product is an oil-in-water emulsion and the administration method is intravenous injection.

In terms of preparation, nanoemulsion preparation processes are mainly divided into two categories: high-energy emulsification method and low-energy emulsification method. High-energy emulsification method is further divided into ultrasonic method, high-pressure homogenization method and shear stirring method. Low-energy emulsification method is further divided into phase Transformation composition method, phase transition temperature method, drop-by-drop addition method, spontaneous emulsification method, etc. The high-energy emulsification method is currently the main method for preparing nanoemulsions, which uses a mechanical source to transfer high energy to break the dispersed phase and the dispersion medium, thereby producing nanoscale preparations. However, this method has high instrument costs, high operating temperatures, and is not suitable for use. Issues such as processing of heat-resistant pesticide active ingredients.

Industry analysts said that compared with ordinary dosage forms, nanoemulsions have many advantages and are widely used in the fields of medicine, food, pesticides, chemicals, etc. The application prospects are broad. From the perspective of industrial production, the current industrialization development of nanoemulsions is still restricted by production costs, production technology and equipment, and there is an urgent need to reduce costs and increase efficiency. In the future, with the iteration of technology and the improvement of localization capabilities of equipment, the application scenarios of nanoemulsions are expected to continue to expand. .