Diethyl malonate is widely used, but the production process needs to be improved.

Diethyl malonate, also known as ethyl malonate and diethyl carrotate, is an important organic synthesis intermediate with the chemical formula C7H12O4. Diethyl malonate appears as a colorless liquid with a sweet ether smell. It is easily soluble in organic solvents such as ether and alcohol, but insoluble in water. Diethyl malonate has high activity and can produce a variety of chemical reactions with organic compounds. It is widely used in the field of fine chemicals.

The synthesis process of diethyl malonate includes malonic acid method and sodium cyanide method. The malonic acid method uses malonic acid and ethanol as the main raw materials, directly produces esterification reaction, and finally produces diethyl malonate. This method has the advantages of high yield and no pollution, but the production cost is high; cyanide The sodium method uses sodium carbonate and chloroacetic acid as raw materials, reacts with sodium cyanide under high temperature conditions to generate cyanoacetic acid, and then adds concentrated sulfuric acid for esterification reaction to finally obtain diethyl malonate. This method is malonic acid. Diethyl ester has a traditional synthesis process, but the production process is complicated and can easily cause environmental pollution.

According to the “2022-2027 Diethyl Malonate Industry In-depth Market Research and Investment Strategy Suggestions Report released by the Industrial Research Center It shows that malonic acid and chloroacetic acid are the main raw materials for the production of diethyl malonate. In 2021, my country’s chloroacetic acid production reached 798,000 tons, a year-on-year increase of 18.5%. Although the output of raw materials continues to grow, it is still unable to meet my country’s production demand for diethyl malonate, causing its market price to remain high for a long time. In September 2022, the market price of diethyl malonate in my country reached 32,000 yuan/ton.

Diethyl malonate is widely used in medicine, dyes, fine chemicals, edible spices, pesticides and other fields. In the pharmaceutical field, diethyl malonate is used as a pharmaceutical intermediate and can be used to produce barbituric acid, ethoxymethylene and alkyl diethyl malonate. Drugs such as chloroquine, barbiturate and norfloxacin are its downstream terminals. product. Norfloxacin is a third-generation quinolone antibacterial drug that can be used to treat prostatitis, gynecological infections, respiratory infections and other diseases caused by sensitive bacteria. In 2021, the total sales of norfloxacin tablets in my country reached 45.61 million yuan. As application demand becomes increasingly strong, my country’s diethyl malonate market will continue to expand.

There are many diethyl malonate manufacturers in my country, but the scale of the enterprises is small, including Wuhan Jiyesheng Chemical, Hebei Chengxin Group, Tianmen Hengchang Chemical, Zibo Nanlin Chemical and Tiande Chemical, etc. Due to factors such as high technical barriers, there is still a certain gap in the quality and output of diethyl malonate in my country compared with overseas developed countries.

Industry analysts said that diethyl malonate has a wide range of applications and the industry has good development prospects. my country’s diethyl malonate industry started late, and there is a certain gap in production technology compared with overseas developed countries. However, as the independent research and development level of local enterprises continues to improve, my country’s diethyl malonate industry will develop in a high-quality direction.