Nokatone has good application prospects and huge market development space in the future.

Nokatone, also known as pomeloone, is a sesquiterpenoid compound. Pure nokatone appears as a crystal. After dilution, it becomes a yellow viscous liquid. It is insoluble in water and soluble in organic solvents such as ethanol. Nokatone is one of the main chemical components in grapefruit. It is also found in bergamot oil, lemon oil, citrus oil, mandarin oil, etc. Nokatone has the smell of pomelo, citrus, and orange, and can be used to prepare various flavors and flavoring formulas. It is widely used in food, cosmetics, tobacco, flavors and fragrances, soft drinks, feed additives and other fields.

In addition, nokalone also has mosquito repellent and insecticide functions. Compared with DEET and other insecticides, nokalone has the advantages of safety, non-toxic, environmentally friendly, and continuous mosquito repellent. In August 2020, the U.S. Environmental Protection Agency (EPA) approved nokatone for use as an insect repellent or insecticide. Nokatone is a botanical pesticide and has broad application prospects in the fields of personal protection, outdoor use, public health, and indoor protection.

my country is the world’s largest insecticide and mosquito repellent market. In recent years, due to consumption upgrades, my country’s insecticide and mosquito repellent market has maintained a growth trend, reaching about 9.5 billion yuan in 2021. The market for traditional insecticides and repellents is growing slowly, and new insecticides and repellents are the main driving force for market growth, among which products such as portable and suitable for mothers and infants are growing rapidly. Nokatone has excellent anthelmintic properties, is safe in source, and is environmentally friendly. It has huge potential for development in the domestic market in the future.

Nokatone was discovered in the 1960s. The preparation process is divided into natural extraction, chemical synthesis, microbial fermentation, etc. Among them, natural nokatone is isolated from grapefruit peel oil and Alaska yellow tar oil. Due to the limited supply of raw materials, natural nokatone Nokatone is more expensive. The preparation process of synthetic nokatone is complex and inefficient. In contrast, microbial fermentation has obvious advantages in terms of efficiency, raw materials, and cost.

Since the precursor substance valencene has a great influence on the final conversion rate of nokatone, how to construct a high-yielding and stable valentene fermentation strain is currently the mainstream exploration direction for the large-scale production of nokatone. According to the “2022-2027 China Nokatone Industry Market In-depth Research and Development Prospects Forecast Report released by the Industrial Research Center, At present, nokatone manufacturers include Evolva of Switzerland, TAISHO Pharmaceuticals of Japan, Sumitomo Chemical, Isobionics of the Netherlands, Oxford Biotrans of the United Kingdom, etc. Among them, Evolva of Switzerland is a leading company in the field of microbial fermentation of nokalone.

Industry analysts said that nokatone has a wide range of applications, and as research continues to deepen, its application scenarios are expected to continue to expand. As a botanical insecticide, nokatone has the characteristics of safety, non-toxicity, and continuous mosquito repellent. Under the background of green development of pesticides, nokalone market development potential is huge. At present, there is no registration certificate number for nokatone in my country, and the market competition is relatively gentle, and first-mover companies are more conducive to seizing the market.