Toluene diisocyanate manufacturer Knowledge Indomethacin Indomethacin

Indomethacin Indomethacin

Indomethacin Structural Formula

Structural formula

Business number 0164
Molecular formula C19H16ClNO4
Molecular weight 357.79
label

indomethacin,

anti-inflammatory indoleic acid,

1-p-Chlorobenzoyl-5-methoxy-2-methylindoleacetic acid,

Indenaxin,

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

Numbering system

CAS number:53-86-1

MDL number:MFCD00057095

EINECS number:200-186-5

RTECS number:NL3500000

BRN number:497341

PubChem number:24278173

Physical property data

1. Character:White crystal. Sensitive to light.


2. Density (g/mL,25/4): Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point (ºC):155162


5. Boiling point (ºC,Undetermined


6. Boiling point (ºC,5.2kPa): Undetermined


7. Refractive index: undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. 2. Molar volume (m3/mol) :269.5


3. isotonic ratio(90.2K)707.6


4. Surface Tension(dyne/cm)47.4


5. Polarizability(10-24cm3)37.49

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: none

6. Topological molecule polar surface area 68.5

7. Number of heavy atoms: 25

8. Surface charge: 0

9. Complexity: 506

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed in4Preserve dry.

Synthesis method

Indomethacin is obtained by diazotization, reduction, acidification, hydrolysis and cyclization of p-aminoanisole.

Purpose

For biochemical research. Biosynthesis of prostaglandins. The It is an anti-inflammatory product with obvious antipyretic effects. It is mainly used for rheumatic arthritis, ankylosing spondylitis, osteoarthritis, etc. that are intolerant to salicylic acid drugs or have insignificant efficacy.

“>P-aminoanisole undergoes diazotization, reduction, acidification, hydrolysis and cyclization to obtain indomethacin.

Purpose

For biochemical research. Biosynthesis of prostaglandins. The It is an anti-inflammatory product with obvious antipyretic effects. It is mainly used for rheumatic arthritis, ankylosing spondylitis, osteoarthritis, etc. that are intolerant to salicylic acid drugs or have insignificant efficacy.

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