Toluene diisocyanate manufacturer Knowledge Phthalylsulfathiazole Phthalylsulfathiazole

Phthalylsulfathiazole Phthalylsulfathiazole

Phthalosulfathiazole Structural Formula

Structural formula

Business number 01W7
Molecular formula C17H13N3O5S2
Molecular weight 403.43
label

Phthalosulfathiazole,

carboxybenzoyl sulfathiazole,

2-[[[4-[(2-thiazolalamino)sulfonyl]phenyl]amino]carbonyl]benzoic acid,

2-[[[4-[(2-Thiazolylamino)sulfonyl]phenyl]amino]carbonyl]benzoic acid

Numbering system

CAS number:85-73-4

MDL number:MFCD00005318

EINECS number:201-627-4

RTECS number:TH8575000

BRN number:359901

PubChem number:24870549

Physical property data

1. Properties: white or off-white crystalline powder


2. Density (g/mL ,25/4℃): Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point (ºC):198-204


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC,5.2 kPa): Undetermined


7. Refractive Index: Undetermined


8. Flash point (ºC): Undetermined


9. Specific optical rotation (º ): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa, 25ºC): Undetermined


12. Saturated vapor pressure (kPa ,60ºC


1. Molar refractive index: 99.25


2. Molar volume (m3/mol):252.6


3. isotonic specific volume (90.2K):771.8


4. Surface Tension (dyne/cm):87.0


5. Polarizability10-24cm3):39.34



Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 8

4. Number of rotatable chemical bonds: 6

5. Number of tautomers: 4

6. Topological molecule polar surface area 162

7. Number of heavy atoms: 27

8. Surface charge: 0

9. Complexity: 643

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

White or off-white crystalline powder. Melting point198-204℃. Slightly soluble in ethanol, almost insoluble in water or chloroform, easily soluble in hydrochloric acid or sodium hydroxide solution, and easily soluble in ammonia water.

Storage method

Sealed at4℃Save in a dry place and away from light.

Synthesis method

Sulfathiazole ( ST) and phthalic anhydride are acylated to obtain crudePST, the finished product is obtained after refining. STand phthalic anhydride and mix thoroughly,140℃reaction1.5h. Add the crude product to water and adjust the pH with liquid caustic soda : 9pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial”>To8, completely dissolved in 40℃Add activated carbon to decolorize for half an hour, filter, and use hydrochloric acid for the filtrate Neutralize topH=5-6, filter, wash the filter cake, dry and pulverize to obtain the finished productPST.

Purpose

Sulfa drugs, used for bacillary dysentery and bacterial ulcerative enteritis.

Reference value for parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 8

4. Number of rotatable chemical bonds: 6

5. Number of tautomers: 4

6. Topological molecule polar surface area 162

7. Heavy Number of atoms: 27

8. Surface charge: 0

9. Complexity: 643

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

White or off-white crystalline powder. Melting point198-204℃. Slightly soluble in ethanol, almost insoluble in water or chloroform, easily soluble in hydrochloric acid or sodium hydroxide solution, and easily soluble in ammonia water.

Storage method

Sealed at4℃Save in a dry place and away from light.

Synthesis method

Sulfathiazole ( ST) and phthalic anhydride are acylated to obtain crudePST, the finished product is obtained after refining. STand phthalic anhydride and mix thoroughly,140℃reaction1.5h. Add the crude product to water and adjust the pH with liquid caustic soda : 9pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial”>To8, completely dissolved in 40℃Add activated carbon to decolorize for half an hour, filter, and use hydrochloric acid for the filtrate Neutralize topH=5-6, filter, wash the filter cake, dry and pulverize to obtain the finished productPST.

Purpose

Sulfa drugs, used for bacillary dysentery and bacterial ulcerative enteritis.

ONT-FAMILY: Arial”>

Purpose

Sulfa drugs, used for bacillary dysentery and bacterial ulcerative enteritis.

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