Related research on phenylthiohydantoin-tryptophan_Kain Industrial Additives

Overview^[1-2]

Phenylthiohydantoin-tryptophan is a white crystal with a special sweet taste. Soluble in water, hot ethanol and sodium hydroxide or potassium hydroxide solution. The levorotatory body is a white flaky crystal, odorless. Melting point: 289°C (decomposition). Soluble in water and hot ethanol, insoluble in chloroform, stable in alkaline solution. The racemate is a white crystal, not easily soluble in water, stable in alkaline solutions, and can be decomposed by strong acids. The natural product is left-handed, [α]_D²⁰ is -38°. It appears deep purple with formaldehyde, mercury sulfate and sulfuric acid, and is commonly used in analytical chemistry to identify its presence. It can be obtained by alkaline hydrolysis and refining of casein, or it can be synthesized with β-indole aldehyde and hippuric acid. One of the essential amino acids for humans, it is formulated with vitamins into an injection solution for trauma patients and surgeries, and is also used as a prevention and treatment agent for pellagra.

Phenylthiohydantoin-tryptophan is used as a pharmaceutical synthesis intermediate. If phenylthiohydantoin-tryptophan is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; If eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.

Preparation^[2]

Synthesis of phenylthiohydantoin-tryptophan via phenylthioisocyanate and DL-tryptophan:

Related research^[2]

IMMS technology, operating as a stand-alone instrument or combined with a high-speed liquid chromatography system, provides additional separation capabilities for the determination of complex mixtures such as phenylisothiocarbamoyl/phenylthioisocyanate-amino acids. and speed. When applied to phenylisothiocarbamoyl/phenylthioisocyanato amino acids separation and detection, IMMS will increase sample throughput by eliminating or reducing the rate-limiting step of chromatography in protein microsequencing.

Main reference materials

[1] Dictionary of organic compounds

[2]Rapidseparationofphenylthiohydantoinaminoacids:ambientpressureion-mobilitymassspectrometry(IMMS)