Nicarbazine

Structural formula

Business number	0492
Molecular formula	C19H18N6O6
Molecular weight	426.38
label	Compounds of 4,4-dinitrobenzene urea and 2-hydroxy-4,6-dimethylpyrimidine, Dipyrimidinol, Nicarbazine, coccidioidin, nicarizine, Complex of 4,4'-dinitrocarboanilide (DNC) and α-hydroxy-4,6-dimethylpyrimidine (HDP), Nicarbazine, dinitrourea pyrimidinol, 1,3-bis(4-nitrophenyl)urea-4,6-dimethylpyrimidin-2-ol (1:1), insect repellent health supplement, Feed additives

• Numbering system
• Physical property data
• Toxicological data
• Ecological data
• Molecular structure data
• Computing chemical data
• More
  • Properties and Stability
  • Storage method
  • Synthesis method
  • Purpose

Numbering system

CAS number:330-95-0

MDL number:mfcd00867204

EINECS number:206-359-1

RTECS number:FE0900000

BRN number:None

PubChem ID:None

Physical property data

1. Properties: yellow or yellow-green powder, odorless and slightly odorless.

2. Density (g/mL, 25/4℃): Not available

3. Relative vapor density (g/mL, Air=1): Not available

4. Melting point (decomposition, ºC): 260-265

5. Boiling point (ºC, normal Pressure): Not available

6. Boiling point (ºC, 5.2kPa): Not available

7. Refractive index: Not available

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8. Flash point (ºC): Not available

9. Specific rotation (º): Not available

10. Autoignition point or ignition temperature (ºC): Not available

11. Vapor pressure (kPa, 25ºC): Not available

12. Saturated vapor pressure (kPa, 60ºC): Not available

13. Heat of combustion (KJ/mol): Not available

14. Critical temperature (ºC): Not available

15. Critical pressure (KPa): Not available

16. Logarithmic value of oil-water (octanol/water) partition coefficient: Not available

17. Explosive upper limit (%, V/V): Not available

18. Lower explosion limit (%, V/V): Not available

19. Solubility: Almost insoluble in water, ethanol, chloroform and ether, slightly soluble in dimethyl Formamide.

Toxicological data

The raw material is toxic to nitroaniline and is easily absorbed through the skin. The maximum allowable concentration in the air is 0.0001%.

Nicarbazine can increase the mortality of chicks when the temperature is as high as 40°C. It is usually prohibited to be used in laying hens.

Ecological data

1. Other harmful effects: This substance may be harmful to the environment, so special attention should be paid to water bodies.

Molecular structure data

None yet

Compute chemical data

1. Reference values ​​for calculation of hydrophobic parameters(XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds :2

5. Number of tautomers: 10

6. Topological molecule polar surface area 174

7. Number of heavy atoms: 31

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8. Surface charge: 0

9. Complexity: 582

10. Number of isotope atoms: 0

11. Determine the atomic position Number of stereocenters: 0

12. Uncertain number of stereocenters of atoms: 0

13. Determined number of stereocenters of chemical bonds: 0

14. No Determine the number of stereocenters of chemical bonds: 0

15. The number of covalent bond units: 2

Properties and stability

None yet

Storage method

None yet

Synthesis method

1. It is formed by the condensation of p-nitroanilide and urea.

2.It is prepared by the cyclization of 4,4'-p-nitro diphenyl urea, acetylacetone and urea. Or it can be prepared from 4,4'-p-nitro diphenyl urea and 2-hydroxy-4,6-dimethylpyrimidine.

Purpose

1. It has a good preventive and therapeutic effect on Eimeria tenella in the cecum, Eimeria tenella in the small intestine, Eimeria giantis and Eimeria Bordoni. For broiler or pullet use only, not for laying hens.

2.It has the advantages of high efficiency, low toxicity, stable performance and low drug resistance. It has a good preventive effect on chicken cecal coccidia, Ehrlichia acervicis, Ehrlichia gigantea, and poisonous Ehrlichia. It is effective against the second generation schizonts of coccidia and is highly safe. Used to prevent chicken and turkey ballworm diseases.